MICROBIOLOGY 101 INTERNET TEXT

CHAPTER XVII: SEXUALLY TRANSMITTED DISEASES

As I get time, I will update the notes. As I write the notes I will link them to items both within the document and to addresses outside on the INTERNET that contain relevant information. I will expect you to view that information. Please note that I put KEY WORDS/TERMS IN BOLD, COLORS AND CAPS. These represent terms, definitions and concepts that I consider important. If you have comments please come to see me or contact me through my E-mail at hurlbert@wsu.edu. I will try to answer any questions within 24 hr (during the week) if possible.

 


Updated: 12/3/96 



 

TABLE OF CONTENTS

  • Sexually Transmitted Diseases
  • Defining STDs
  • Description of Some Common STDs
  • How to Avoid Catching a STD
  • Introduction to AIDS
  • AIDS Myths
  • The Cause of AIDS the Disease
  • The Course of AIDS
  • AIDS Therapy
  • AIDS Future
  • Social Problems Associated with AIDS


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    SEXUALLY TRANSMITTED DISEASE

    INTRODUCTION

    "It (STD) is taken when one pocky person doth synne in lechery one with another"; a moral perspective on STDs, which, morality aside, aptly describes the human dilemma permeating this problem.

     


    Sexually transmitted diseases or STDs present a unique Public Health problem. Before continuing I wish it to be CLEARLY UNDERSTOOD that I am dealing with the problem of STDs strictly as a medical and microbial issue and not as a moral or religious question. In spite of this disclaimer, there will be those who upon reading this material will take it that I am PREACHING MORALS to them. Let me assure you that the microbes involved are not the least interested in your or my morals, they only want to survive and they will adapt their pathogenic behavior to FIT THE BEHAVIOR OF THEIR HUMAN HOSTS. Therefore, from a strictly evolutionary standpoint we humans have it within our power through our SOCIAL ATTITUDES AND BEHAVIOR to CONTROL these diseases; a power we lack over many other diseases. Morality aside it is a BIOLOGICAL FACT that changes in human behavior could ELIMINATE STDs as a serious disease problem.

    All forms of life have a powerful INSTINCT to procreate and I have presented the genetic reason for sex being a required part of the process of reproduction. In the case of STDs, human reproductive drive (instinct?) combines with human intellect and social development to produce a complex situation and one that we humans haven't yet dealt with successfully . The dilemma humans face are the facts that (1) STDs require sexual activity for their transmission; (2) humans require sexual activity to procreate and; (3) powerful reward systems are built in to the performance of the STD-transmission act (sexual intercourse). The STD microbes might best be viewed as DEADLY HITCHHIKERS on a natural process we are rewarded for doing.



     

    GOALS OF STD SECTION

    The learning goals are:

    To learn what sexually transmitted diseases are.

    To learn the characteristics and epidemiology of some major STDs.

    To learn, in detail the epidemiology and disease characteristics of the HIV virus.

    To learn how STDs may be dealt with both medically and socially. 



     

    HOW MUCH DO YOU KNOW ABOUT STDs; A SELF TEST OF YOUR KNOWLEDGE

    EXTRA CREDIT: Send me your answers via E-mail by the beginning of this lecture (no answers accepted after). Those that get 11 or more correct get 4 extra points. See the correct answers after the STD lectures have begun.

    Answer the following: In your E-mail letter, put the answers in a column labeled #1-13, beside the appropriate number. Alternatively, copy the questions into your E-mail and delete the incorrect answers for each.

    1. All persons with STDs have obvious symptoms. T or F
    2. Only people with visible or open STD sores are contagious. T or F
    3. No vaccine exists for any STD. T or F
    4. Vaginal infections are inconvenient but not dangerous. T or F
    5. My child is not at risk. T or F
    6. Washing for men and douching for women prevents STDs. T or F
    7. STDs are no worse than a bad cold. T or F
    8. How many people in America came down with an STD in 1995?
    9. How many Am carry some type of STD?
    10. How many people in the US are infected with genital herpes (GH)?
    11. How many new cases of GH in the US were reported in 1995?
    12. How many people in the US were infected with chlamydia in the US in 1995?
    13. How many people in the US became infected with genital warts in 1995?
    How did you do? Don't feel bad if you didn't know the answers to these questions, as few people do. The larger concern is that you may someday have sex with someone who is unaware of the extent of the STD problem. 

     

    DEFINING STDs AND THE STD "PROBLEM"

    "Remember, hormones always win over neurons" Advice given to Dr. Karl Johnson by his father as he left home for college. From talk by Dr. Karl Johnson at WSU Nov. 6, 1995.

     


    STDs are infectious diseases that are primarily transmitted through the ACT OF SEXUAL INTERCOURSE. Their portals of entry are the GENITOURINARY TRACK and the ANUS. They mainly infect the reproductive organs, but several STDs can spread throughout the body. STDs may be transmitted in other ways, usually involving the sharing of blood or other body fluids through the aggressive invasion of the body with needles, knives or other sharp instruments.

    No discussion of STDs is possible without considering the impact of SOCIAL AND RELIGIOUS ATTITUDES. STDs are as much a social as a medical problem. We humans have trouble thinking rationally about anything having to do with sex. Sex pushes OUR BUTTONS in several significant ways. Sex is highly emotional, it makes us uncomfortable, it embarrasses us, it treads on all sorts of taboos and provokes irrational and often mean-spirited responses from people. The role of social and religious perspectives will be considered from the position of the EFFICACY OF TRANSMISSION of the STDs. Imposed upon this already horrendously complex problem are political issues, homophobia, myths, fears, guilt, economic considerations and malignant ignorance. I shall attempt to tread light through this virtual mine field, but please feel free to express your REASONED views and perspectives with me and the class either in class or via e-mail.

    Let us attempt to put aside our prejudices and negative baggage on this issue and try for a while to deal with it strictly as a MICROBIAL PROBLEM



     

    DESCRIPTION OF SOME MAJOR STD

    WARNING: Click here to view the STD HOMEPAGE which contains graphic pictures of STDs that some will find disgusting and all normal people will find gross. If these picture "turn-you-on" please seek help immediately!

     


    Fig. 2 shows some recent relative STD numbers. Note that although AIDS is receiving the most attention because of it fatal outcome, it is still a minimal problem from a numbers standpoint. The estimate for new AIDS cases in the US for 1995 is 97,800. The average cost for medical treatment for a single AIDS case is $119,000 (Health Mag. Nov./Dec. 1995; Sci. Am. Feb. pg 62, 1991)).
     


    Figure 2. Relative numbers of several of the more common STDs. Although AIDS represents a relatively small number of STD cases, because of its high mortality rate it is receiving much more attention. The relative high cost of AIDS treatment increases its significance.


     

    EXERCISE ON USE OF CDC FOR INFORMATION

    REQUIRED READING: Click here to go to the CDC WONDER site. When at that site proceed as follows:
    1. Go to "Guidelines & Reports" site.
    2. Go to latest "STD Surveillance Report" site.
    3. Go to "National Profile" site.
    4. Read about "Chlamydia and Gonorrhea" and be prepared to answer the following questions on the exam:

    GONORRHEA

    Gonorrhea, GC or the "CLAP", is the most COMMONLY REPORTED STD. It is caused by a G- coccus, Neisseria gonorrheae, that attaches to the urethra with special PILI or FIMBRIAE. The symptoms are VERY DIFFERENT in the male and female. Female symptoms are usually a mild vaginitis that is similar to a variety of other vaginal infections. Because of their mild nature these symptoms may go UNNOTICED and UNTREATED. In the male pus and swelling in the urethra cause painful & and frequent urination which generally elicits an excited visit to a doctor, however 10% of the males are asymptomatic. The bacteria may infect the eyes, particularly of babies at birth, and can lead to blindness. Because GC often goes untreated in women, they serve as the MAJOR RESERVOIR. GC often leads to STERILITY in both sexes if left untreated. There is NO IMMUNITY and a cured individual can catch the disease OVER AND OVER AGAIN. Although GC is still treatable with antibiotics, antibiotic resistant strains are appearing and many physicians fear we will lose the ability to treat this disease with antibiotics. Condoms offer some protection against catching GC. GC can also infect the mouth, throat and anus. Often an individual with GC has several STDs. Some individuals spontaneously recover from a GC infection. Click here for a discussion from the STD Homepage.

    NONGONOCOCCAL URETHRITIS

    This disease, known as NGU, is caused by ANY INFLAMMATION OF THE URETHRA not due to GC. There is often painful urination and a watery discharge. There are 3 to 5 million new cases per year, while complications are rare, sterility in women is common. There are several microbes that may be involved, but the major one is Chlamydia urethritis. Antibiotics will usually treat the condition. However, many women don't have clear symptoms or ignore them until it is too late and they are sterile. The failure to recognize the symptoms and obtain medical treatment contributes to the spread of the disease.

    PULLMAN IS NUMBER ONE in the state in diagnosed C. urethritis. It is the No. 1 STD and the No. 1 cause of sterility. There is no immunity, no vaccine and one may get repeated infections.

    SYPHILIS

    This STD is cause by the G- spirochete Treponema pallidum. It is transmitted mainly by sexual intercourse. The disease commonly passes through 3 stages; a primary, secondary and tertiary stages. The Primary stage produces a lesion at the initial site of infection, usually on the penis or the wall of the vagina. This heals up spontaneously. Many cases are cured by the natural defense system. If not, the organisms may travel to other parts of the body and the secondary stage occurs producing skin rashes and hair loss. During the secondary stage the patient is highly infectious. In the 3rd stage there usually is involvement of the nervous system leading to the destruction of the brain, insanity, blindness and death. Click here to see what a syphilis lesion looks like. Click here for a discussion from the STD Homepage.

    GENITAL HERPES: HERPES IS FOREVER!

    There are two strains or types of herpes virus, type 1 and type 2, both caused by strains of Herpes simplex. The type 1 causes cold sores and mainly infects the mouth region. Type 2 herpes is the genital form. About 2 weeks after infection lesions, redness, swelling, itching, blisters and a burning occurs in the genital region, including the anus. The blisters crust over in about 3 weeks and disappear. Future attacks last about 5 days. The virus lives in the nerve cells where they remain for life. Some people have frequent attacks, some only one and some have sporadic reoccurrence. Attacks may be tied to stress including the menstrual cycle, illness, fatigue, emotional stress etc. Although type I predominates ABOVE THE WAIST, 20% of the genital herpes is due to this type. The type II predominates BELOW THE WAIST, but it can infect THE MOUTH AREA. A common myth is that if you don't see the blisters you are not infective. This is strictly bull scat spread by people who generally are trying to talk others into having sex with them (run, don't walk from anyone who tells you this). While you may be less infective if no lesions are visible, you can still be infective.

    The disease is RARELY FATAL in adults, but it is OFTEN LETHAL to new born babies who pick up the infection in the birth canal. Most women with herpes choose to have Cesarean birth to prevent infection of the baby. Certain anti-viral drugs lesson the period of attacks and some people take these drugs prophylactically. There are Herpes Help Groups that put people with herpes in contact with one another for dating etc. Try the Internet for help groups. Anyone who has herpes and doesn't tell their sex partners is not a person of HONOR in my opinion. Click here for a discussion from the STD Homepage.
     


    AIDS: A MODERN PLAGUE

    INTRODUCTION

    AIDS is mainly a STD and a disease of intravenous drug (IV) users. As a STD AIDS requires for its transmission that humans be PROMISCUOUS. That is, AIDS is NOT CAUGHT EASILY; it is not transmitted in the air, water, food, insect bites or by contacts between people that doesn't involve the exchange of body fluids. It is caught by an EXCHANGE OF BODY FLUIDS, mainly blood. The cycle of HIV transmission is EASILY BROKEN, at least in theory. In short, AIDS is almost entirely a disease of LIFE STYLE. HIV is a retroviruses and their unusual method of replication has been described.

    Although almost everyone has heard of AIDS by now, there is much confusion as to its nature, just how dangerous it is, how you catch it and when and if there will ever be a cure or a vaccination. These subjects will be discussed in this section. The effect of the HIV virus can only be understood through an understanding of the specific immune system.

    For information on AIDS on the www:

    Page on TB & relationship to HIV: http://www.brown.edu/Research/TB-HIV_Lab/About_TB/TB_Title.html

    Biology of AIDS: http://www.bocklabs.wisc.edu/Tutorial.html

    Listing of AIDS Web Information: gopher://odie.niaid.nih.gov/11/aids

    CDC Reports on AIDS: gopher://gopher.niaid.nih.gov:70/11/aids/cdcds

    Picture of HIV: http://pavlakislab.ncifcrf.gov/pictures.html

    AIDS MYTHS THAT CAN KILL YOU

    The following are some of the major myths that surround the AIDS problem. They are fed by prejudice, plain ignorance, willful ignorance, religious dogma and a human characteristic of trying to make complex things easy. If you have some comment on the following please contact me.

    AIDS IS A DISEASE OF HOMOSEXUALS & IS A PUNISHMENT FOR THEIR SINS: This is a tough one to deal with since the concept of "SIN" is a theological matter, not a scientific issue. The closest scientific thing to a religious sin might be engaging in BEHAVIOR that has been proven to be PHYSICALLY HARMFUL such as smoking, overeating, under exercising, excessive drinking of alcohol and engaging in promiscuous sex. Each of these activities has been proven to lead FREQUENTLY to a DISEASE STATE, and most of us engage in one or more of these "BIOLOGICAL SINS" to some degree (guess which one(s) I do?). To the degree that homosexuals, particularly the males, engage in promiscuous, unsafe sex, they contribute significantly to the spread of the HIV virus.
     


    "ONE OF THE FASTEST-GROWING AIDS POPULATION IN THE US IS TEENAGERS….NUMBER OF AIDS CASES IN 13-19-YEAR-OLDS INCREASED 524% IN 1ST SIX MONTHS OF 1995……MOST OF THIS INCREASE OCCURRED AMONG GAY TEENAGERS…." From Dateline: NIAID Sept. 1996 


     


    This situation is not unlike the epidemic of syphilis that struck the world in the 15th century, only in this case it was HETEROSEXUAL PROMISCUOUS sex that rapidly disseminated this disease. The major FLAW IN THIS MYTH is simply that AIDS strikes both homo- and heterosexuals ALIKE once they are infected, by whatever means, with the HIV virus. The growth of the virus and the course of the disease is EXACTLY THE SAME in both groups. It doesn't matter if the victim is a baby whose mother was an IV drug user, a hemophiliac, a surgeon who cut himself during an operation on a HIV carrier, a homosexual male prostitute, a heterosexual female prostitute, or a college student who got drunk and did a stupid thing only once.

    AIDS IS A DISEASE MAINLY OF AFRICAN AMERICANS: There is no doubt that HIV infection is much higher in poor communities, be they white, black, Asian or Spanish American. But AIDS is a disease of poverty, ignorance, drugs, life-style and hopelessness. The HIV virus is equally infective in every race on this planet as far as we know today. It is truly an "equal opportunity killer". The latest data however, indicates that one of the fastest areas of HIV infection is occurring in the Black Inner Cities, mainly among teenagers (NBC NEWS 12/1/1996).

    I CAN TELL WHO IS LIKELY TO HAVE AIDS; NONE OF MY FRIENDS ARE "DIRTY"; NO ONE I KNOW WOULD HAVE SEX WITH SOMEONE WITH AIDS ETC.: These are the myths of people who have decided they WANT TO HAVE SEX with someone and no fact, logic or reason is going to interfere with their high time. In effect the primitive reptilian parts of their brains have effectively eliminated their "thought processes". Such "reasoning" often follows the intake of a pint or so of strong drink in a brief period of time or an excessive libido. When someone tells you this I would run, not walk, to the nearest exit, because you're not dealing with someone whose operating on all cylinders; they are a few cards shy of a full deck; they are half-a-bubble off plumb; they're missing a CPU. Certainly I would not let such people invest my money for me, drive my new car or baby-sit my kids. I will give anyone an A in the course if they can provide me with a foolproof way of telling who is infected with HIV just by looking at them; any takers?

    AIDS CAN BE CAUGHT BY GIVING BLOOD: Not unless you're using the Fly-By-Night-Vampire Blood Mobile. If the nurse spit-cleans the site of inserting the needle and wipes the needle off on her skirt before sticking it in you, you may indeed have a problem with any number of diseases including AIDS. However, this doesn't happen with legitimate blood collecting agencies. To my knowledge no one has ever caught the HIV virus from GIVING BLOOD.

    AIDS WAS MANUFACTURED BY THE CIA AND KGB TO KILL AFRICAN AMERICANS or BY THE WORLD HEALTH ORGANIZATION TO CONTROL POPULATION: These are a very prevalent rumors which exists in several versions (my father happens to believe this story). A survey in the Fall of 1995 reported that approximately 1/3 of African Am. believe the first one to be true. While it is THEORETICALLY POSSIBLE to "make" a virulent virus, we simply don't know enough about the virulence of HIV or any other virus, to modify it that way, much less to manufacture one that could selectively infect humans of a certain skin color. What-ever-the-case, the fact that it is EQUALLY VIRULENT to all humans says something about the POOR QUALITY of any research that produced it (maybe it was the CIA----just kidding fellows?). If HIV was manufactured, the guys that did it were INCOMPETENT and shouldn't expect the Nobel Prize committee to consider them for any awards.

    YOU CAN CATCH AIDS FROM YOUR ROOMMATE, LAB PARTNER, PERSON WHO SITS BESIDE YOU IN CLASS, FROM DIRTY DISHES, SHARING A BEER OR FROM THE TOILET: There is always the off chance that under EXACTLY THE RIGHT KIND of conditions you could catch AIDS in one of the ways described above, but it is HIGHLY UNLIKELY, unless you are HAVING SEX with any of those people. Actually the HIV virus seems remarkably difficult to catch. If it wasn't that millions of humans were happily and enthusiastically working night 'n day trying to give it to each other, the poor virus would probably not survive for long. Why if we changed our behavior we might even see the formation of a "SAVE THE AIDS VIRUS" (or SAV) organization; they wouldn't ask you for money, only that you go out and engaged in unsafe sex with a lot of people. They'd push for laws fining anyone who didn't have unsafe sex at least 10 times a year (5 affairs for married people).

    I CAN ENGAGE IN ALL THE UNSAFE SEX I WANT BECAUSE I CAN'T GET AIDS: Anyone who thinks this is not just illogical, but is the type of person who would go sky diving WITHOUT A PARACHUTE and want you to join them. People who think like this (using the word "think" to describe such a process is an oxymoron) are running on empty; their one brain cell is asleep, they are retards etc.

    SOME PEOPLE SURVIVE AIDS: This may indeed be true, but it is in the category of saying that "some people have fallen 3 miles from an air plane without a parachute and survived". Which, even though it is TRUE, leaves the person who hears it wondering if their hearing is functioning. Among the 5.6 billion people on this planet there are some who have survived HIV infection for >15 years. Eight individuals have an unusual weakened strain of HIV that may protect them from the virulent form. However, unless you travel to Australia where they live and have sex with them, the odds you will contact a NONLETHAL HIV appear to be so small that this would be you (or me) that to even consider it has to raise serious questions about one's sanity and intelligence.



     

    THE DISEASE AIDS

    The following is a summary of what we know (or think we know) about the HIV virus at the moment and the disease called AIDS. (Sci Am. Aug. pg 58 1995).

    AIDS is caused by the HIV virus or Human Immunodeficiency Virus. There are a few other hypotheses kicking around that other agents cause it, including environmental ones (industrial pollution), but there is no SCIENTIFIC EVIDENCE to back any of them up. Obviously Koch's Postulates can not be used to prove that HIV is the etiological agent of AIDS, since we can not use humans as test animals and our near primate relatives don't seem as susceptible to HIV as are humans They do suffer from a simian form called SIV. The overwhelming epidemiological, and biochemical data supports the conclusion that HIV is the etiological agent of AIDS. Recently (Nov. 10, 1995) it was reported that the first chimpanzee given the HIV virus has comes down with a classical case of AIDS after 9 years.

    AIDS is a disease of the immune system. Its method of attack is DIABOLICAL. If I were to design the perfect pathogen it would resemble the HIV virus. For example, most HIV positive individuals progress to AIDS over a 10 to 15 year period, during most of that time they are reasonably healthy, capable of being sexually active, and HIGHLY INFECTIVE. This 6 to 10 years of infectivity meets perfectly the requirements of an efficient pathogen; one that doesn't kill its host before it can past the pathogen on. Further, the fact that the HIV virus is not highly infectious supports its subtle, but effective spread; i.e., by spreading out the time of transmission it insures that large "clusters" of victims don't die all at once and produce a "shock effect" that might change people's sexual behavior.

    We now know that HIV has the FASTEST MUTATION RATE of any virus known. This means that it can change its antigenicity rapidly, developing new varieties quickly to meet new immunological and drug treatment challenges. But how does HIV cause AIDS and why does the disease progress so slowly? Within these questions apparently lie the terrible secret of the success of HIV.

    THE COURSE OF AIDS

    The problem with HIV lies not so much in a failure of our immune system, it is that HIV has developed a way to subvert the immune system:

    Upon infection with HIV the body recognizes a foreign agent and immediately launches a vigorous counterattack. First, macrophages and related cells engulf and digest the HIV into smaller proteins.

    The HIV epitopes are presented to the special T HELPER CELLS or HELPER T LYMPHOCYTES. The Th cells secrete chemicals that stimulate the appropriate epitope-recognizing Tk and B cells to proliferate. The B cells proliferate and differentiate into plasma cells and begin secreting large quantities of antibody against HIV. The Tk cells or killer T lymphocytes seek out, attack and kill any cells that harbor HIV. The HIV-antibodies bind to these infected cells and target them for destruction by complement and Tk cells.

    However, the major target cell of HIV are the Th cells THEMSELVES and Th-cells initially die by the thousands, until the Tk cell and HIV-antibodies are produced and counterattack. Victims may show some mild to severe (e.g. flu-like) symptoms during this early attack. However, many show no symptoms and they all recover and remain SYMPTOM-FREE for an extended period.

    During the second phase the immune system continues to function well (this is the phase Magic Johnson is currently in). How then does HIV survive? Why isn't it DESTROYED COMPLETELY early in the struggle? The virus level remains low, however the NET VIRUS LEVEL begins to slowly increase and the helper T cells continue a SLOW DECLINE. The decline is apparently brought about by a COMBINATION of the effects of HIV infection and destruction of the Th by the Tk cells they have activated. Recall however, that the Th cells are required for the ACTIVATION OF BOTH the Tk and B cells.

    It turns out that the reverse transcriptase that makes DNA from the retrovirus's RNA is seriously error prone. This means that it makes more mistakes (mutations) than any virus known. To understand the significance of this we must invoke the theory of evolution The high mutation rate means that HIV has a tremendous evolutionary potential.

    This evolutionary potential is seen in the production of mutant strains of HIV that are not longer recognized AS FOREIGN by the immune system. When one of these strain arises it infects Th cells and produces more HIV. The immune system responds in its normal manner described above. But there is a difference, and that is that the immune system is now weakened by the loss of Th cells so its response is slower and less effective.

    Figure 2. The evolutionary cycle of HIV mutation. Mutants arise spontaneously. A rare mutant is not recognized by the immune system and is able to infect more Th cells. This mutant is eventaully recognized as foreign antigen and an attack is mounted against it. However, new mutations continually arise until the bulk of the Th cells are destroyed (as shown by some viruses escaping destruction by a weakened immune system in bottom left) and the immune system collapses.

    The cycle of mutations producing new strains, re-infection and fresh replication of the new HIV strain followed by a response by the damaged Immune system. The cycle continues relentlessly and the numbers of Th drops inexorably lower and lower.

    When it reaches 200 Th per microliter from a high of 1000, the victims fate is sealed. The symptoms of AIDS becomes full blown, the viral level climbs sharply and all the measures of immunity (e.g. antibody level, Th cells etc.) drop precipitously. The victims rarely survives for more than two years after this stage is reached.

    Death occurs when the victim succumbs to opportunistic infections that overwhelm the victims last defenses.

    Figure 3. The course of AIDS through the effects on the various components involved. The key data are the patterns of HIV and Th concentrations over time. HIV levels initially show a sharp rise, but once the immune system is fully activated the HIV level falls to very low levels. However, a few mutant HIV survive and infect the Th cells. The body again responds to the mutant HIV-antigen and the HIV level falls; as indicated by the wavy character of the HIV data line (blue). During this repeating cycle of mutation, re-infection the number of Th cells decline as they are killed by HIV and by the bodies own Tc cells (red). Eventually, the concentration of Th cells declines to a point where it can no longer activate the immune system, which then collapses and allows many different opportunistic pathogens to overcome the host. 


    AIDS THERAPY

    The approaches to dealing with AIDS fall into three categories: At the present time only the third approach has shown ANY ENCOURAGING SIGNS OF SUCCESS (Time http://pathfinder.com/@@aTqMPlHzTQAAQOiN/time/magazine/domestic/1996/960212/cover.aids.html; I don't know how long this link will function). A series of new drugs were recently (Spring '96) released which suggest the possibility of living longer with the HIV infection. Further, research results are suggesting that the earlier the treatment the longer it takes for AIDS to develop. With a battery of drugs that attack the HIV at a variety of stages, the chance of HIV mutants developing decreases.

    Some drugs have had the effect of making the late stages of an AIDS's victim less painful and there has been some success at fighting certain of the most common opportunistic infections that afflict those in their final stages. The drug AZT inhibits the transfer of HIV from the infected mother to the fetus if given early in pregnancy.

    Currently drugs like AZT are aimed at the enzyme reverse transcriptase .Newer drugs include HIV-proteinase inhibitors. HIV-proteinases are required for the virus to mature. Because both these enzymes are unique to the virus they are reasonable points to attack. However, the rapid mutation rate of HIV results in it becoming resistant to AZT within ~18 months on average. Another approach has to do with inhibiting the binding of the virus to the target cells; to blocking or otherwise stopping the binding to the unique receptors on the cells that HIV attacks.

    It also appears that some babies born with HIV are able to totally eliminate the virus. How they manage this is being intensely studied in hopes it will provide clues to HIV treatment. However, currently not even the most optimistic scientist believes that a cure is anywhere in the near future.

    As discussed above the most logical, simplest and most effective approach would be a CHANGE IN THE SEXUAL BEHAVIOR OF HUMANS. That this can work has been shown by the effects of an aggressive educational campaign among the American homosexuals. In the 1980s the homosexual community sought to educate that group in safe sexual practices. It appears to have been successful as the number of new AIDS cases among homosexuals FELL SIGNIFICANTLY. However, as older gays have died from AIDS and the numbers of gays with AIDS declined, the younger gays are reported to have lost their fear of this disease and there is evidence that the old ways of unsafe sex are returning.

    The problem safe-sex education is complicated by religious. political and moral views that feel that anything but TOTAL SEXUAL ABSTINENCE is wrong and that all sex education is wrong except that performed by parents. Such groups also feel that it is immoral to teach people how to use condoms or any other safe-sex procedures because it promotes immoral behavior. Do you have views on this subject? If so let me know and I'll pass it on to the class (without your name attached). 


    AIDS FUTURE

    Right now this is anyone's guess. The world's HIV-infection numbers are currently (Fall 1995) estimated to be 18 million. AIDS has reached pandemic proportions in parts of central Africa where there are reports of whole villages disappearing because everyone has died of AIDS. Further, thousands of children have become orphans because all their family members have died of AIDS. HIV infection is extremely high in the large population centers in central Africa where less than one dollar per person per year is spend on health care. Many governments in Africa refuse to admit that there is a serious HIV problem or even that there is any problem for fear of losing tourist dollars or causing unrest among their population.

    Southeast Asia and India are predicted to be the next centers of AIDS outbreaks. In Thailand over 1 million people out of a population of 60 million are infected with HIV. There they have found infection rates of 38% in commercial sex workers, 12% in Royal Thai Army recruits and 16% among men using STD clinics. In Asia HIV infection is almost EXCUSIVELY HETEROSEXUAL in nature and the virus seems to have evolved to be more infective in the heterosexual situation. The Thai government has undertaken an extensive educational program of safe sexual practices which is reported to be having a significant effect.

    Further, new strains of HIV are being reported, some which seem better able to establish an infection via the vaginal route and others the anal route. It would appear that either evolution is working pretty much as predicted or, if you believe that the CIA/KGB made the virus, they are still at it and someone should find out where they're doing this work and ask them to please stop (I'm being sarcastic here folks, so don't take that last statement seriously).

    One glimmer of hope has come from a recent finding (Sci. Nov. 1995) that 8 people in Australia that were infected with a weakened mutant of HIV 15 years ago have not developed AIDS and may even be resistant to catching the virulent form of HIV. It is speculated that this weakened form of HIV, or some derivative of it, might serve as a LIVE VACCINE to immunize people against HIV. How many of you would allow yourself to be vaccinated with a LIVE HIV? See TIME Nov. 20, pg 100 1995. http://pathfinder.com/@@RZ4NcnHtIwMAQL9V/time/magazine/domestic/1995/951120/medicine.html


    AIDS RELATED PROBLEMS & SOCIETY

    FAQ by WELL BEHAVED but scientifically illiterate people: "why should I worry about a bunch of people who willfully and knowingly engage in unsafe sex and/or shoot up drugs? Maybe the best thing to do would be to let them get on with committing suicide and let that solve the problem!"

    ANSWER: Well that attitude might be all right if biology wasn't involved or if the person asking that question never had to worry about meeting other humans. However, there are serious CONSEQUENCES if nothing is done about HIV.

    THE COST: It now costs >$100,000 to treat a person with AIDS and that cost is usually borne by society (read TAXPAYER or just fill in your name). It doesn't take a rocket scientist to multiply the number of HIV infected people by 100,000 to come up with a rather humongous, I mean seriously huge, like mind-boggling monstrous, number that has to come out of our pockets. At a time when society is trying to limit spending on medical care, it would seem this presents somewhat of a fiscal dilemma.

    TUBERCULOSIS: The TB bacterium is, unlike HIV, ridiculously easy to catch. Further, it is tough as nails and lasts one hellish long time outside the host. TB is spread through the air, food and water. Finally, if you're not pale, and feeling sick to your stomach yet, consider that new antibiotic resistant forms of TB have developed which makes treatment virtually impossible.
     



     


    "What does this have to do with AIDS anyway?" you alertly ask? Gee I'm glad you asked that question (pick your bribe up after class); let me tell you a SHORT STORY with a definite MICROBIAL TWIST.

    ONCE UPON A TIME it seems there were all these sick people with this nasty disease called AIDS, which we good and decent people didn't get (we told ourselves) because we are so darn cute, neat and wonderful. However, the evil witch, Mother Nature and her toady companion Evolution, didn't think we good people were all that wonderful except as nutrient-rich mobile-lumps of juicy meat. So the two of them brewed up something rather nasty to get our attention.

    It seems that people who have AIDS are immunologically COMPROMISED (but you knew that) and all sorts of microbes love to grow in them, including the TB bacillus. So when Joe, one of our friendly homosexual, homeless AIDS patients, goes in for treatment at the local free-clinic, it's found that he has a bloody awful fulminating case of TB (bummer!). Antibiotics are prescribed and Joe is told that he has to take the medication every day for the rest of his short miserable, pain filled life. Poor Joe stumbles out of the clinic, takes the crowded subway and, being at heart a friendly, sharing person, infects the 50 or so people pressed up against him with his TB. He's rather depressed at the additional rotten news, so he goes on a two-week drunk & forgets to take his medication. But he has taken just enough to begin to select out RESISTANT STRAINS OF HIS TB BACILLUS. He doesn't bother to return to the clinic to pick up more TB medication since he knows he's going to die soon and they can't do anything about it. In the meantime he's become a one-man-coughing-walking-sitting-beside-you-on-the-bus/subway/movie foci of antibiotic resistant TB. Joe will be remembered by many of us when we get our next chest X-ray and find out that he's left us with something that just keeps on giving.

    See report on recent spread of TB: http://www.the-scientist.library.upenn.edu/yr1996/feb/hot2_960205.html
     



     


    So what do we as a society with the Joes out there? Do we leave those with HIV infections to the not-so-tender mercies of mother nature, who uses Joe and his buddies as walking cultures for things like new strain of TB and other nasties which may eventually infect you and me?

    THE LOSS OF TALENT: AIDS has taken a terrible toll of creative male homosexuals in this country and is on its way towards taking many lives of young heterosexuals around the world. Is this a loss we want to have happen? Will the world be better off with the death of these young people, who after all are our brothers, sons, cousins and uncles?

    DISRUPTION OF SOCIETIES: As societies have to expend increasingly amounts of their limited resources in caring for those ill from AIDS and related diseases (e.g. TB), and as many of its CREATIVE young professionals die from AIDS, it will DESTABILIZE these societies once those costs exceed a certain amount. For example, they will not be able to pay off their debts which may, in turn, disrupt the world's banking system. Since the world's economy seems to be IRREVOCABLY LINKED, can we expect to avoid problems from these disruptions in banking and trade?

    SHIFTING OF RESOURCES TO MEDICAL CARE FROM OTHER NEEDS: As limited resources are required to treat the burgeoning ill population, this takes money and manpower from other creative activities such as education, maintaining the industrial infrastructure, research etc.

    AIDS SUMMARY

    In writing this section I have tried to walk a fine line between depression, despair and education. AIDS is perhaps the most SERIOUS PROBLEM to face mankind since the possibility of an Atomic holocaust during the Cold War. It is very difficult to learn about this problem and not be discouraged. The solution seems so tantalizingly close, yet it remains out of reach because we are prisoners of our human nature. We appear to be in a race between education and reason on the one hand and ignorance and blind, sexual instinct on the other, and the former seems to be losing, at least at the moment. If you have any workable suggestions or thoughts on the subject please share them with me & I will use my judgment to pass them on to the readers of these files. Thank you. 

    OTHER STDs

    There are a number of other important STDs that we don't have time to cover in this course. These include Hepatitis B, and papilloma virus. 

    HOW TO AVOID CATCHING STDs

    The prevention of STDs is actually VERY SIMPLE. It doesn't require morals, ethics, that you be a religious or non-religious person, or that you are even a law abiding person. It does require that you HAVE KNOWLEDGE and that you UTILIZE THAT KNOWLEDGE. The microbes that are responsible for STDs all depend upon humans ENGAGING IN OODLES OF UNPROTECTED SEX to transmit them. Without that activity most STDs would VIRTUALLY DISAPPEAR from the earth in one or two generations. Consider that the microbes evolve to take advantage of human behavior not vice versa. The following is a list of simple steps you can take to minimize your chances of contracting a STD (please avoid laughing until you've finished reading them).

    Avoid having sex until marriage and then remain MONOGAMOUS within the marriage (I'm serious).

    Know the ENTIRE SEXUAL HISTORY of everyone with whom you are going to have sexual intercourse. Remember that MICROBIOLOGICALLY you are having sex with EVERYONE your partners have had sex with in their past. When you buy a used car you inquire into its history and it can't give you a fatal disease.

    Sexually active individuals planning to have sex together should have an exam for STDs, including an AIDS test, and, if either has had sex with anyone else, they should NOT HAVE SEX with anyone for three to six months before having a second AIDS test to VERIFY that BOTH ARE FREE of the HIV virus. (This defines WILL POWER).

    Never have UNPROTECTED sex unless you have followed I through III. Condoms offer some degree of protection against all STDs. However, the "heat of passion" often renders condoms less effective.

    I'm sorry that I can't offer you any easy answers to A VERY DIFFICULT PROBLEM. I am very aware that the ABOVE CHOICES are, in today's social & moral climate, so difficult as to make them comical. However, I know some people who have followed these rules and they seem perfectly normal, well adjusted and happy. However, the characteristics of the STDs don't leave me any alternatives. You may choose not to take the above advice seriously, but that will be like not taking gravity seriously when you're sky-diving. 


    Copyright © Dr. R. E. Hurlbert, 1996. This material may be used for educational purposes only and may not be duplicated for commercial purposes.

    E-mail address: hurlbert@wsu.edu

    Phone: 509-335-5108

    Fax: 509-335-1907

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